Lipase activity in the human aorta
نویسندگان
چکیده
منابع مشابه
Lipase activity in the human aorta.
The hydrolysis of triglycerides by grossly normal male human aortas has been studied in vitro. The tissue contains an acid lipase (pH optimum, 5.4) and an alkaline lipase (pH optimum, 8.8). Both lipases catalyze the hydrolysis of saturated triglycerides; the rate decreases with increasing fatty acyl chain from C(10) to C(18). Glycerol trioleate, trilinoleate, and trilinolenate are hydrolyzed at...
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The mechanisms following intimal injury predisposing towards atherosclerotic changes have not been fully elucidated. We speculated that a local increase in the enzyme lipoprotein lipase (LPL) might explain a higher susceptibility of the damaged intima to lipid accretion, and so we investigated the effect of balloon endothelial denudation on LPL activity and cholesterol content (LPLa and Cholc, ...
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15 صفحه اولExpression of lipoprotein lipase mRNA and secretion in macrophages isolated from human atherosclerotic aorta.
The expression of lipoprotein lipase (LPL) mRNA and the LPL activity were studied in macrophages (CD14 positive) from human atherosclerotic tissue. Macrophages were isolated after collagenase digestion by immunomagnetic isolation. About 90% of the cells were foam cells with oil red O positive lipid droplets. To analyze the mRNA expression, PCR with specific primers for LPL was used. Arterial ma...
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]n the thronibogenic theory of the pathogenesis of arteriosclerotic lesions, parietal fibrin deposits in the arteries play a primary role. In an effort to elucidate the heinostatic system in the arterial wall, the thromboplastic activity and the fibrinolytic activity (estimated as plasminogcn activator) in the layers of the human aorta have been estimated. The simultaneous presence of high thro...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1970
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)42985-2